ISSA Nutritionist Practice Exam 2026 – Comprehensive All-In-One Guide to Exam Mastery!

Apolipoprotein E (ApoE) plays a critical role in lipid metabolism, particularly in the uptake and reabsorption of lipids by specific tissues. It is primarily synthesized in the liver and is essential in the transport and clearance of triglyceride-rich lipoproteins. ApoE facilitates the binding of lipoproteins to specific receptors, enhancing the reabsorption of lipids in the liver. This process is vital for maintaining lipid homeostasis in the body, as it allows the liver to process and regulate the utilization and storage of lipids effectively.

In the context of the other options, skeletal muscle mainly utilizes fatty acids for energy but does not primarily reabsorb lipids in the same manner as the liver. Adipose tissue is involved in the storage of lipids but relies on different mechanisms for fatty acid uptake. Intestinal tissue is primarily responsible for the initial absorption of dietary lipids rather than their reabsorption after they have been processed in circulation. Therefore, the focus on the liver as the site where ApoE is responsible for lipid reabsorption is justified and aligns with established physiological roles.